Dihydroberberine: The Next Generation Berberine Solution

Dihydroberberine: The Next Generation Berberine Solution

We often receive inquiries about our top-selling product, Berberine Advance. What distinguishes us is our use of Dihydroberberine, a formulation developed by Shawn Wells MPH, LDN, RD, CISSN, FISSN, renowned as the world’s leading nutritional biochemist and an expert in health optimization.

Shawn's expertise shines through his innovative approach, with over 1100 groundbreaking formulations under his belt, including 40 patented ingredients, amongst which Dihydroberberine stands out.


We've collaborated with Shawn's team to delve into the finer details of Dihydroberberine and why it's the natural choice when selecting a berberine supplement.

Benefits of Dihydroberberine: Dihydroberberine outshines standard berberine in multiple aspects. Its advantages include:

  • Improved Glucose Metabolism: Dihydroberberine aids in regulating blood sugar levels, making it particularly beneficial for individuals managing their glucose levels. Moreover, its association with AMPK activation fosters longevity and resilience.
  • Enhanced Lipid Metabolism: This compound supports lipid metabolism, contributing to ideal cholesterol, lipids and cardiovascular function.
  • Anti-inflammatory Properties: Dihydroberberine modulates inflammation , which is key to maintaining optimal health and longevity.
  • Weight Management: Research suggests that Dihydroberberine facilitates weight management and reduces body fat by enhancing energy expenditure and curbing appetite and cravings. Its mechanism as a GLP1 agonist adds an exciting dimension to its weight management potential.

Common Issues Associated with Standard Berberine: While standard berberine offers several health benefits, it comes with its share of challenges, including:

  • Low Bioavailability: Standard berberine suffers from poor oral bioavailability, meaning a significant portion is metabolized before it can exert its effects.
  • Gastrointestinal Distress: Some individuals may experience gastrointestinal side effects such as diarrhea, constipation or abdominal discomfort, especially at higher doses.

Main Differences Between Standard Berberine and Dihydroberberine:

  • Bioavailability: Dihydroberberine, unlike standard berberine, doesn't require conversion in the gut, resulting in significantly higher bioavailability. This means more of the active compound reaches the bloodstream, enhancing its beneficial effects.
  • Reduced Side Effects: Thanks to its improved absorption, Dihydroberberine is associated with fewer gastrointestinal side effects compared to standard berberine.

Best Time to Take Dihydroberberine and Recommended Schedule:

Optimal timing for Dihydroberberine intake may vary depending on individual goals, but general recommendations include:

  • With Meals: Taking Dihydroberberine with or before meals maximizes its glucose disposal and lipid metabolism benefits, synergizing with food intake to regulate blood glucose and lipid levels.
  • Recommended Schedule: A common dosing schedule is 100-200 mg twice daily, but it's advisable to adhere to the manufacturer's instructions or consult a healthcare provider for personalized advice.

Factors to Consider When Purchasing a Dihydroberberine Supplement:

  • Purity and Quality: Look for supplements containing the branded and patented form known as GlucoVantage, tested for purity and quality by third-party organizations. 
  • Dosage: Ensure the supplement provides a dose aligned with current research and recommendations.
  • Manufacturer Reputation: Opt for products from reputable manufacturers with positive reviews and transparent production processes.
  • Additives: Be cautious of any additional ingredients that may be unnecessary or undesirable.

Potential Side Effects of Berberine and Benefits of Dihydroberberine:

Berberine may cause gastrointestinal issues and, at high doses, potentially affect liver function. Dihydroberberine, however, tends to avoid these side effects while offering additional benefits such as improved efficacy and reduced adverse reactions.

Here are some practical tips to manage these gastrointestinal side effects:

  • Begin with a lower dosage and gradually increase it. This gives your body time to adjust to the supplement.
  • Drink plenty of water. It’s simple but effective. Water helps your digestive system run smoothly and can alleviate some of the discomfort.

In conclusion, our Berberine Advance which uses Dihydroberberine emerges as a superior alternative to standard berberine, offering enhanced bioavailability and a host of health benefits with fewer associated side effects.


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